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KMID : 1134120190220010141
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Journal of Breast Cancer
2019 Volume.22 No. 1 p.141 ~ p.148
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Durable Response of Androgen Receptor-Positive Male Breast Cancer to Goserelin
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Azim Hamdy Abdel
Kassem Loay
Shohdy Kyrillus Samaan
Eshaak Boules
Anis Shady Elia
Kamal Nermine Shawky
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Abstract
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The luteinizing hormone-releasing hormone/androgen receptor (LHRH/AR) pathway is a promising treatment target in a subgroup of female patients with triple-negative breast cancer (TNBC). However, very little is known about the efficacy of this strategy in male patients with TNBC. In this report, we describe a male patient with AR-positive TNBC who was successfully treated using an LHRH agonist after pretreatment with several lines of chemotherapy and achieved a durable response. We also review the existing evidence supporting LHRH- and AR-targeted therapy for this rare disease.
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KEYWORD
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Luteinizing hormone-releasing hormone, Androgen receptor, Triple-negative breast neoplasms
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